This quantity presents a realistic, complete evaluation on benign and malignant ailment of the grownup kidney. The textual content addresses the subject of overview and administration of sufferers with surgical renal illness. inside of this scope, it comprises hereditary and spontaneous renal neoplasms, in addition to non-neoplastic disorder that manifests as a clinically suitable mass. The booklet is geared up into chapters concentrating on discrete sickness entities and incorporating pathology, surgical administration, oncologic remedy, radiologic findings, and molecular changes. this article is designed to deal with correct components of medical administration of renal neoplastic and non-neoplastic ailment throughout a number of specialties and degrees of training.
Written by way of specialists within the box, The Kidney: A accomplished consultant to Pathologic analysis and administration is a helpful source at the prognosis and administration of sufferers with not just renal cellphone carcinoma, but additionally different renal methods that require surgical intervention.
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Additional info for The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management
5 Coronal CT scan view of a patient with ADPKD. Note the derangement of normal renal architecture by innumerable large renal cysts. Some small liver cysts are also noted on this view without a family history of disease. The diagnosis of ADPKD can be established with the presence of two or more renal cysts along with a polycystic liver, an ICA, or pancreatic cysts . The use of axial imaging is not strictly necessary to diagnose ADPKD. However, CT and MRI can be useful adjuncts in the monitoring of disease progression or for assisting in the diagnosis of complicated presentations (Fig.
25 In a retrospective analysis of 240 ADPKD patients who underwent renal surgeries, 12 (5 %) patients presented with malignant lesions. Two-thirds of these patients had undergone dialysis prior to surgery. Of the malignant tumors identiﬁed, 63 % were papillary RCC, 31 % were clear cell RCC, and 6 % had papillary noninvasive urothelial carcinoma . Other characteristics associated with ADPKD patients who develop RCC include diagnosis at a younger age, bilateral tumors (12 % vs. 1–5 % in the general population), multicentric tumors (28 % vs.
11. Reeders ST, Breuning MH, Davies KE, Nicholls RD, Jarman AP, Higgs DR, Pearson PL, Weatherall DJ. A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature. 1985;317(6037):542–4. 12. Ryynanen M, Dolata MM, Lampainen E, Reeders ST. Localisation of a mutation producing autosomal dominant polycystic kidney disease without renal failure. J Med Genet. 1987;24(8):462–5. 13. Qian F, Watnick TJ, Onuchic LF, Germino GG. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.
The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management