By Diana Gabaldon
Lord John gray, a lieutenant-colonel in His Majesty's military, arrives in Jamaica with orders to quash a slave uprising brewing within the mountains. yet a far deadlier danger lies shut handy. The governor of the island is being menaced by way of zombies, in response to a servant. Lord John has no proposal what a zombie is, however it doesn't sound stable. It sounds even worse while fingers smelling of grave airborne dirt and dust pop out of the darkness to take him by way of the throat. among homicide within the governor's mansion and plantations burning within the mountains, Lord John will want the knowledge of serpents and the success of the satan to maintain the island from exploding.
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Extra resources for A Plague of Zombies (Lord John Grey, Book 3.5)
Diagnostic methods for investigating iron metabolism The large amount of iron present as haemoglobin means that the degree of any anaemia must always be considered in assessing iron status. Reduced amounts of haemoglobin accompany an overall reduction in body iron in iron deficiency anaemia or after acute blood loss. In other anaemias, including the anaemia of chronic disease and most haemolytic and megaloblastic anaemias, iron is redistributed from the red cells to macrophage iron stores, with a corresponding increase in marrow-stainable iron and serum ferritin.
4-kDa glycoprotein, found in serum at baseline levels of 5–25 iU/L that can be elevated 1000fold by severe anaemia. It contains about 40% carbohydrate, is rich in sialic acid residues, and has a half-life of 7–8 hours in plasma, whereas non-glycosylated Epo is rapidly cleared from the circulation. The main site of Epo production is the interstitial cells of the kidney. Under normoxic conditions, little or no Epo mRNA is detectable in the kidneys; hypoxia results in the rapid induction of its transcription such that levels may increase up to 200-fold over baseline within 30 minutes.
Epo upregulation is accomplished through a hypoxiaresponse element (HRE) at the 3′ -end of the Epo gene. Under hypoxic conditions, HIF-1α is stabilized and can bind to the HRE of the Epo gene (and other hypoxia-sensitive genes), to increase transcription and therefore increase serum Epo levels. The positive effect of HIF is greatly increased by two cofactors, HNF-4, and the coactivator CBP/p300, also under hypoxic control. Linking Epo production to tissue oxygenation ensures that when there is reduced ambient oxygen tension, blood loss or shortened red cell survival, the level of Epo rises, stimulating red cell production and ultimately providing a greater source of local oxygen delivery.
A Plague of Zombies (Lord John Grey, Book 3.5) by Diana Gabaldon