By Meir Shalev
From the across the world acclaimed Israeli author Meir Shalev comes a spell binding novel of 2 love tales, separated through part a century yet hooked up by way of one mesmerizing act of devotion.
During the 1948 struggle of Independence--a time whilst pigeons are nonetheless used to carry battlefield messages--a talented younger pigeon handler is mortally wounded. within the moments ahead of his loss of life, he dispatches one final pigeon. The chicken is wearing his outstanding present to the lady he has enjoyed when you consider that formative years. Intertwined with this tale is the modern story of Yair Mendelsohn, who has his personal legacy from the 1948 warfare. Yair is a travel consultant focusing on bird-watching journeys who, in heart age, falls in love back with a formative years female friend. His growing to be ardour for her, in addition to a present from his mom on her deathbed, turns into the major to a lifestyles he concept now not attainable.
Unforgettable in either its details and its sweep, A Pigeon and A Boy is a story of enthusiasts then and now--of how deeply we like, of what house is, and why we, like pigeons educated to fly in a single path purely, needs to ultimately go back to it. In a voice that's instantly playful, clever, and altogether beguiling, Meir Shalev tells a narrative as common as battle and as intimate as a winged statement of affection.
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Additional info for A Pigeon and a Boy: A Novel
Diagnostic methods for investigating iron metabolism The large amount of iron present as haemoglobin means that the degree of any anaemia must always be considered in assessing iron status. Reduced amounts of haemoglobin accompany an overall reduction in body iron in iron deficiency anaemia or after acute blood loss. In other anaemias, including the anaemia of chronic disease and most haemolytic and megaloblastic anaemias, iron is redistributed from the red cells to macrophage iron stores, with a corresponding increase in marrow-stainable iron and serum ferritin.
4-kDa glycoprotein, found in serum at baseline levels of 5–25 iU/L that can be elevated 1000fold by severe anaemia. It contains about 40% carbohydrate, is rich in sialic acid residues, and has a half-life of 7–8 hours in plasma, whereas non-glycosylated Epo is rapidly cleared from the circulation. The main site of Epo production is the interstitial cells of the kidney. Under normoxic conditions, little or no Epo mRNA is detectable in the kidneys; hypoxia results in the rapid induction of its transcription such that levels may increase up to 200-fold over baseline within 30 minutes.
Epo upregulation is accomplished through a hypoxiaresponse element (HRE) at the 3′ -end of the Epo gene. Under hypoxic conditions, HIF-1α is stabilized and can bind to the HRE of the Epo gene (and other hypoxia-sensitive genes), to increase transcription and therefore increase serum Epo levels. The positive effect of HIF is greatly increased by two cofactors, HNF-4, and the coactivator CBP/p300, also under hypoxic control. Linking Epo production to tissue oxygenation ensures that when there is reduced ambient oxygen tension, blood loss or shortened red cell survival, the level of Epo rises, stimulating red cell production and ultimately providing a greater source of local oxygen delivery.
A Pigeon and a Boy: A Novel by Meir Shalev